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One-step Protocol for Evaluation of the Mode of Radiation-induced Clonogenic Cell Death by Fluorescence Microscopy
Published on: October 23, 2017
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Radiation-Induced Cell Death: Signaling and Pharmacological Modulation
1Department of Oncohematology, R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine.
Critical Reviews in Oncogenesis
|June 29, 2018
Summary
Radiation therapy is crucial for cancer treatment, but tumor resistance and side effects are challenges. This review explores regulated cell death (RCD) pathways and modulators to improve radiotherapy outcomes.
Area of Science:
- Oncology
- Radiation Biology
- Molecular Biology
Background:
- Radiotherapy is a cornerstone of cancer treatment, utilized by over half of newly diagnosed patients.
- Tumor radioresistance and treatment-related side effects significantly limit radiotherapy's efficacy.
- Regulated cell death (RCD) pathways play a critical role in the response to radiation in both cancerous and normal tissues.
Purpose of the Study:
- To review the major signaling pathways governing radiation-induced RCD.
- To discuss novel therapeutic strategies involving the biological modulation of RCDs.
- To highlight advances in small-molecule RCD modulators for enhancing radiotherapy.
Main Methods:
- Literature review of signaling pathways involved in radiation-induced RCD.
- Analysis of current research on RCD modulation in preclinical and clinical settings.
- Discussion of small-molecule RCD modulators, including natural and synthetic compounds.
Main Results:
- Ionizing radiation triggers various RCD pathways, influencing treatment response.
- Targeting RCD offers a promising strategy to overcome radioresistance and mitigate toxicity.
- Small-molecule modulators show potential for improving the therapeutic window of radiotherapy.
Conclusions:
- Understanding RCD pathways is essential for optimizing radiotherapy.
- Modulating RCD presents a novel therapeutic avenue to enhance tumor killing and reduce side effects.
- Development of small-molecule RCD modulators holds significant promise for future cancer treatment.
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