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Acetylcholine Receptor Stimulation for Cognitive Enhancement: Better the Devil You Know?

Mark G Baxter1, Johanna L Crimins1

  • 1Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.

Neuron
|June 29, 2018
PubMed
Summary

Targeting acetylcholine to improve memory may be counterproductive. Direct M1 muscarinic acetylcholine receptor stimulation impaired prefrontal cortex neuronal activity crucial for working memory, challenging existing drug development strategies.

Keywords:
Alzheimer’s diseasecholinergicdementia

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