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Updated: Feb 8, 2026

Assessing Respiratory Immune Responses to Haemophilus Influenzae
Published on: June 29, 2021
Nontypeable Haemophilus Influenzae Sepsis in a Term Neonate
Saki Okubo1, Kazumichi Fujioka1, Megumi Yamane2
1Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.
Abstract:
We reported a term newborn case of early onset sepsis caused by nontypeable Haemophilus Influenzae (NTHi) with massive bacterial invasion in the placenta. Based on the consistent results of maternal placental pathology and neonatal bacterial culture, we diagnosed this as vertical transmission of NTHi via vaginal delivery. In general, NTHi infections occur in preterm infants, and our term infant case is very unusual. In conclusion, clinicians should consider NTHi as a cause of neonatal sepsis, even in term infants.
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