Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Weak Base Solutions03:21

Weak Base Solutions

25.3K
Some compounds produce hydroxide ions when dissolved by chemically reacting with water molecules. In all cases, these compounds react only partially and so are classified as weak bases. These types of compounds are also abundant in nature and important commodities in various technologies. For example, global production of the weak base ammonia is typically well over 100 metric tons annually, being widely used as an agricultural fertilizer, a raw material for chemical synthesis of other...
25.3K
Weak Acid Solutions04:02

Weak Acid Solutions

43.3K
Few compounds act as strong acids. A far greater number of compounds behave as weak acids and only partially react with water, leaving a large majority of dissolved molecules in their original form and generating a relatively small amount of hydronium ions. Weak acids are commonly encountered in nature, being the substances partly responsible for the tangy taste of citrus fruits, the stinging sensation of insect bites, and the unpleasant smells associated with body odor. A familiar example of a...
43.3K
IR Spectrum Peak Intensity: Amount of IR-Active Bonds00:55

IR Spectrum Peak Intensity: Amount of IR-Active Bonds

1.1K
When infrared radiation is passed through a molecule, absorption occurs if the molecule's vibration leads to a substantial change in its bond dipole moment. Transitions between vibrational energy levels, typically corresponding to infrared frequencies (4000–400 cm−1), allow absorption if the vibration significantly alters the dipole moment, making the molecule infrared active. The molecular bonds have different stretching and bending vibrations, resulting in various peaks with...
1.1K
Measurement: Standard Units03:38

Measurement: Standard Units

81.3K
Every measurement provides three kinds of information: the size or magnitude of the measurement (a number), a standard of comparison for the measurement (a unit), and an indication of the uncertainty of the measurement. While the number and unit are explicitly represented when a quantity is written, the uncertainty is an aspect of the errors in the measurement results.
81.3K
Titration of a Weak Acid with a Weak Base01:08

Titration of a Weak Acid with a Weak Base

5.0K
Weak acids and bases do not undergo dissociation completely, and titrations between these two are rarely studied. When such studies are performed, say, for the titration of a weak acid with a weak base, the titration curve plots the change in pH as a function of the volume of base added. Take the titration of acetic acid with ammonia, for instance. During the titration, these two species form ammonium acetate and water, but the pH change is slow and gradual.
As a result, there is no simple...
5.0K
Measurement: Derived Units03:02

Measurement: Derived Units

55.9K
The International System of Units or SI system, by international agreement, has fixed measurement units for seven fundamental properties: length, mass, time, temperature, electric current, amount of substance, and luminosity. These are called the SI base units.
55.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Alarms and alarm management with automated versus conventional ventilation in neurocritical care patients.

Intensive & critical care nursing·2026
Same author

(f)Utility of cEEG after cardiac arrest should not be judged by its unique prognostic contribution.

Critical care (London, England)·2026
Same author

Quality of life after tranexamic acid in subarachnoid hemorrhage: post-hoc analysis of the ULTRA trial.

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation·2026
Same author

Decreased functional connectivity in post-COVID syndrome patients with high neuroinflammatory activity.

NeuroImage·2026
Same author

Herpes simplex virus type 2 encephalitis in critically ill adults: A retrospective analysis of EURECA and Herpetics cohort studies.

Critical care (London, England)·2026
Same author

Intravenous methylprednisolone as add-on induction therapy for chronic inflammatory demyelinating polyradiculoneuropathy: a randomised controlled trial.

Journal of neurology, neurosurgery, and psychiatry·2026
Same journal

Towards haplotypes of blood group genes: the impact of long-read sequencing in molecular immunohematology.

Annals of translational medicine·2026
Same journal

Development of pharmacological interventions for the treatment of sarcopenia.

Annals of translational medicine·2026
Same journal

Fertility preservation in young women with breast cancer: a narrative review of effectiveness, oncologic safety, and clinical practice implications.

Annals of translational medicine·2026
Same journal

Propofol-based total intravenous anesthesia and recurrence-free survival after hepatectomy-does it improve outcomes?

Annals of translational medicine·2026
Same journal

Is pulmonary hypertension still a contraindication for lung volume reduction?-a narrative review of contemporary evidence.

Annals of translational medicine·2026
Same journal

Calcium montmorillonite clay: a clinically oriented narrative review of emerging perioperative and supportive applications.

Annals of translational medicine·2026
See all related articles

Related Experiment Video

Updated: Feb 8, 2026

Monitoring Lung Function with Electrical Impedance Tomography in the Intensive Care Unit
05:56

Monitoring Lung Function with Electrical Impedance Tomography in the Intensive Care Unit

Published on: September 6, 2024

6.3K

No association between systemic complement activation and intensive care unit-acquired weakness.

Esther Witteveen1,2,3, Luuk Wieske1,2,3, Friso M de Beer1,2

  • 1Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

Annals of Translational Medicine
|June 30, 2018
PubMed
Summary
This summary is machine-generated.

Critically ill patients show complement activation, but this does not differ between those who develop intensive care unit-acquired weakness (ICU-AW) and those who do not. This finding suggests complement activation is not a specific marker for ICU-AW development.

Keywords:
Complement activationcritical illness myopathycritical illness polyneuropathyintensive care unit-acquired weakness (ICU-AW)systemic inflammation

More Related Videos

A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit
09:57

A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit

Published on: July 13, 2019

13.8K
A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats
05:56

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats

Published on: February 20, 2021

2.5K

Related Experiment Videos

Last Updated: Feb 8, 2026

Monitoring Lung Function with Electrical Impedance Tomography in the Intensive Care Unit
05:56

Monitoring Lung Function with Electrical Impedance Tomography in the Intensive Care Unit

Published on: September 6, 2024

6.3K
A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit
09:57

A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit

Published on: July 13, 2019

13.8K
A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats
05:56

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats

Published on: February 20, 2021

2.5K

Area of Science:

  • Critical care medicine
  • Immunology
  • Neurology

Background:

  • Intensive care unit-acquired weakness (ICU-AW) is a significant complication in critically ill patients.
  • Sepsis, systemic inflammatory response syndrome (SIRS), and multiple organ dysfunction are key risk factors for ICU-AW.
  • These risk factors are linked to systemic complement activation.

Purpose of the Study:

  • To investigate whether critically ill patients who develop ICU-AW exhibit increased systemic complement activation compared to those who do not.
  • To explore the role of complement activation products (C3b/c, C4b/c, C5a) in the development of ICU-AW.

Main Methods:

  • Plasma samples were collected from ICU patients on mechanical ventilation for ≥48 hours over 6 days.
  • Complement activation products (C3b/c, C4b/c, C5a) were measured.
  • ICU-AW was defined by a mean Medical Research Council (MRC) score <4.

Main Results:

  • Increased levels of C4b/c were observed in all patients.
  • No significant differences in admission, maximum, minimum, or mean levels of complement activation products were found between patients who developed ICU-AW and those who did not.
  • Muscle strength measurements and complement assays were performed on 27 patients, with 13 developing ICU-AW.

Conclusions:

  • Systemic complement activation is present in critically ill patients.
  • Complement activation levels do not differentiate between patients who develop ICU-AW and those who do not.
  • The study does not support the hypothesis that increased systemic complement activation is a predictor of ICU-AW.