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A Quiet Disease With Loud Manifestations.
Benjamin Louis Moresco1, Melissa Dziuk Svoboda1, Yu-Tze Ng1
1Department of Pediatrics, Baylor College of Medicine, The Children's Hospital of San Antonio, San Antonio, TX.
Seminars in Pediatric Neurology
|July 3, 2018
Summary
Cytomegalovirus (CMV) is a common congenital virus causing sensorineural hearing loss and developmental delays. Neuroimaging findings, often overlooked, can reveal abnormalities related to congenital CMV.
Area of Science:
- Neurology
- Infectious Diseases
- Pediatrics
Background:
- Cytomegalovirus (CMV) is the leading cause of congenital viral infection in the US and a primary cause of acquired sensorineural hearing loss.
- Congenital CMV can lead to significant neurological deficits, including sensorineural hearing loss and developmental delays.
Observation:
- A 15-month-old girl presented with progressive sensorineural hearing loss and developmental delays.
- Brain MRI revealed extensive white matter abnormalities, initially misdiagnosed as leukodystrophy.
Findings:
- The patient's neurological abnormalities were ultimately attributed to congenital CMV infection.
- This case highlights the under-recognition of neuroimaging findings associated with congenital CMV.
Implications:
- Congenital CMV should be included in the differential diagnosis for infants with white matter hyperintensities, sensorineural hearing loss, or developmental delays.
- Increased provider awareness of CMV's neurological impact is crucial for timely diagnosis and management.
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