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Related Concept Videos

Anatomy of the Heart01:27

Anatomy of the Heart

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The human heart is made up of three layers of tissue that are surrounded by the pericardium, a membrane that protects and confines the heart. The outermost layer, closest to the pericardium, is the epicardium. The pericardial cavity separates the pericardium from the epicardium. Beneath the epicardium is the myocardium, the middle layer, and the endocardium, the innermost layer. There are four chambers of the heart: the right atrium, the right ventricle, the left atrium, and the left ventricle.
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Percutaneous tricuspid annuloplasty.

Marissa Donatelle1, D Scott Lim2,3

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Severe tricuspid regurgitation (TR) affects millions, often leading to heart failure. This review explores novel transcatheter annuloplasty devices as alternatives to surgery for repairing the tricuspid valve.

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Area of Science:

  • Cardiovascular Medicine
  • Interventional Cardiology
  • Biomedical Engineering

Background:

  • Severe tricuspid regurgitation (TR) impacts 1.6 million Americans, with 85% being functional TR.
  • Untreated TR leads to right-sided heart failure, high morbidity, and mortality.
  • Surgical repair is the standard but underutilized, creating a need for alternative treatments.

Purpose of the Study:

  • To review novel direct and indirect transcatheter annuloplasty devices for severe tricuspid regurgitation.
  • To highlight advancements in percutaneous tricuspid valve repair technologies.

Main Methods:

  • Review of current literature on transcatheter tricuspid valve repair devices.
  • Analysis of direct (e.g., Cardioband) and indirect (e.g., TriCinch, Trialign) annuloplasty systems.
  • Discussion of anatomical challenges in percutaneous transcatheter annuloplasty.

Main Results:

  • Percutaneous transcatheter annuloplasty offers an alternative to conventional surgery for TR.
  • Direct and indirect annuloplasty systems are modeled after surgical techniques.
  • Ongoing development addresses anatomical challenges for improved percutaneous repair.

Conclusions:

  • Transcatheter tricuspid valve repair is a rapidly advancing field.
  • Novel devices show promise for treating severe TR, addressing limitations of surgical repair.
  • Further innovation is needed to overcome anatomical challenges in percutaneous annuloplasty.