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Longitudinal Changes in Bleb Height, Vascularity, and Conjunctival Microcysts After Trabeculectomy
Arjunan Kumaran1,2, Rahat Husain1,2, Hla M Htoon2
1Singapore National Eye Centre.
Journal of Glaucoma
|July 3, 2018
Summary
Early microcysts after trabeculectomy correlate with lower intraocular pressure (IOP). Bleb height decreases over time, and bleb vascularity
Area of Science:
- Ophthalmology
- Glaucoma Surgery
- Surgical Outcomes
Background:
- Trabeculectomy is a common glaucoma surgery.
- Bleb morphology changes over time post-surgery.
- 5-Fluorouracil (5-FU) is used to enhance trabeculectomy outcomes.
Purpose of the Study:
- To investigate longitudinal changes in bleb morphology after trabeculectomy.
- To assess the impact of 5-Fluorouracil (5-FU) on bleb characteristics.
- To determine the relationship between bleb morphology and intraocular pressure (IOP) over 36 months.
Main Methods:
- Retrospective analysis of a randomized controlled trial.
- Subjects received trabeculectomy with 5-FU or placebo.
- Bleb morphology (microcysts, height, vascularity) and IOP were monitored for up to 36 months.
Main Results:
- Microcyst presence peaked early and was associated with lower IOP.
- Mean bleb height decreased over 36 months.
- Bleb vascularity decreased initially and then stabilized.
Conclusions:
- Early post-trabeculectomy microcysts are linked to reduced IOP.
- Bleb height reduction reflects remodeling, with complex IOP-vascularity relationships.
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