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Synthesis of Substrate-Bound Au Nanowires Via an Active Surface Growth Mechanism

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Published on: July 18, 2018

An ultra-fast mechanically active cell culture substrate.

Alexandre Poulin¹, Matthias Imboden¹, Francesca Sorba^1,2

¹Institute of Microengineering, École Polytechnique Fédérale de Lausanne, CH-2002, Neuchâtel, Switzerland.

Scientific Reports

|July 4, 2018

Summary

We developed a compact cell stretcher using a dielectric elastomer actuator (DEA) to simulate physiological and extreme mechanical forces on cells. This tool enables high-speed cell stretching and compression for mechanobiology research.

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Microfabricated Platforms for Mechanically Dynamic Cell Culture

Microfabricated Platforms for Mechanically Dynamic Cell Culture

Published on: December 26, 2010

Area of Science:

Mechanobiology
Biomaterials
Cellular Mechanics

Background:

Cellular responses to mechanical stimuli are crucial in physiology and disease.
Existing cell stretching devices often lack the capability for high strain rates or complex strain patterns.

Purpose of the Study:

To develop and characterize a novel, compact cell stretcher capable of generating high strain rates and complex mechanical deformations.
To enable live-cell imaging during mechanical stimulation for mechanobiology research.

Main Methods:

A dielectric elastomer actuator (DEA) comprising a silicone membrane and stretchable electrodes was fabricated.
High voltages (kV range) were applied to the DEA to induce mechanical strain in cultured cells.
The device's strain capabilities (tensile and compressive), speed, and strain rates were quantified.

Main Results:

The cell stretcher achieved up to 38% tensile and 12% compressive strain.
Strain rates as high as 870 s^-1 (87%/ms) were generated in under 1 ms.
The transparent device is compatible with live-cell microscopy, allowing real-time observation.

Conclusions:

The developed DEA cell stretcher offers a unique platform for studying cell mechanics under dynamic physiological and extreme conditions.
This technology can address fundamental questions in mechanobiology, including strain-rate dependent injury mechanisms and cytoskeletal dynamics.