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Updated: Feb 8, 2026
Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Chronic kidney disease is associated with carotid atherosclerosis and symptomatic ischaemic stroke
Nobuo Kajitani1, Haruhito A Uchida2, Isao Suminoe3
11 Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Insights
Chronic kidney disease (CKD) is linked to increased carotid atherosclerosis, a condition where arteries harden. This association may contribute to a higher risk of symptomatic ischemic stroke in patients with CKD.
Area of Science:
- Cardiovascular Medicine
- Nephrology
- Neurology
Background:
- Chronic kidney disease (CKD) is a global health concern.
- Carotid atherosclerosis and ischemic stroke are significant causes of morbidity and mortality.
- The relationship between CKD, carotid atherosclerosis, and stroke requires further elucidation.
Purpose of the Study:
- To investigate the association between chronic kidney disease (CKD) and carotid atherosclerosis.
- To determine the relationship between CKD, carotid atherosclerosis, and symptomatic ischemic stroke.
Main Methods:
- A cohort of 455 patients undergoing carotid ultrasonography was analyzed.
- Patients were categorized based on the presence of symptomatic ischemic stroke and chronic kidney disease.
- Carotid intima-media thickness (IMT), internal carotid artery stenosis, and plaque size were assessed.
Main Results:
- Patients with CKD exhibited significantly higher mean IMT compared to those without CKD, even after adjusting for cardiovascular risk factors.
- Estimated glomerular filtration rate (eGFR) showed a negative correlation with IMT in stroke patients (r = -0.169).
- Mean IMT, plaque size, and internal carotid artery stenosis were significant determinants of symptomatic ischemic stroke. Lower eGFR was independently associated with an increased risk of symptomatic ischemic stroke (OR = 0.868).
Conclusions:
- Chronic kidney disease is associated with increased carotid atherosclerosis.
- CKD may be an independent risk factor for symptomatic ischemic stroke.
- These findings highlight the importance of considering renal function in the assessment and management of patients with cerebrovascular disease.
Abstract:
Objective We aimed to investigate the relationships among chronic kidney disease (CKD), symptomatic ischaemic stroke, and carotid atherosclerosis. Methods We enrolled 455 patients who underwent carotid ultrasonography in our hospital, including 311 patients with symptomatic ischaemic stroke and 144 patients without symptomatic ischaemic stroke. Carotid intima-media thickness (IMT), the rate of internal carotid artery stenosis, and maximal plaque size were evaluated. Results The mean age of the patients was 68.5 ± 11.0 years and the mean estimated glomerular filtration rate (eGFR) was 68.8 ± 18.2 mL/min/1.73 m2. After adjustment for cardiovascular risk factors, the mean IMT was significantly higher in patients with CKD than in those without CKD. The IMT and eGFR were negatively correlated in patients with stroke (r = -0.169). Multiple logistic regression analyses showed that mean IMT, plaque size, and internal carotid artery stenosis were significant determinants of symptomatic ischaemic stroke after adjustment of multivariate risk factors. Furthermore, the eGFR was a negative determinant of symptomatic ischaemic stroke after adjusting for classical risk factors (odds ratio [95% confidence interval] = 0.868 [0.769-0.979]). Conclusion CKD might be associated with the carotid atherosclerosis and symptomatic ischaemic stroke.
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