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Novel Therapeutic Targets for Managing Dyslipidemia
Vasanth Sathiyakumar1, Karan Kapoor1, Steven R Jones1
1Ciccarone Center for the Prevention of Cardiovascular Disease, Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Trends in Pharmacological Sciences
|July 5, 2018
Summary
Novel targets like apoprotein C3 and lipoprotein(a) offer new ways to treat atherosclerotic cardiovascular disease (ASCVD) beyond standard statin therapy. Research into these targets may improve prevention and treatment strategies for lipid metabolism disorders.
Area of Science:
- Cardiovascular Medicine
- Genetics
- Pharmacology
Background:
- Atherosclerotic cardiovascular disease (ASCVD) is a major global health concern.
- Current treatments focus on lipid modulation via HMG-CoA reductase inhibition.
- Emerging genetic and observational data highlight new molecular targets.
Purpose of the Study:
- To review novel molecular targets for lipid and lipoprotein metabolism.
- To explore therapeutic potential beyond statin therapy for ASCVD.
- To summarize genetic evidence and ongoing drug development for these targets.
Main Methods:
- Review of Mendelian studies and genetic sequencing data.
- Analysis of prospective longitudinal cohort findings.
- Examination of therapeutic agents in development and early outcomes.
Main Results:
- Identification of apoprotein C3, angiopoietin-like proteins 3 and 4, and lipoprotein(a) as key targets.
- Evidence supporting their role in lipid metabolism and ASCVD.
- Emerging therapeutic strategies targeting these pathways are under investigation.
Conclusions:
- Novel targets offer promising new avenues for ASCVD prevention and treatment.
- Targeting these pathways may complement or enhance current lipid-lowering strategies.
- Further research and clinical trials are warranted to validate these novel therapies.
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