Stability of Antibacterial Silver Carboxylate Complexes against Staphylococcus epidermidis and Their Cytotoxic
Maialen Aldabaldetrecu1, Laura Tamayo2, Romina Alarcon3
1Faculty of Chemistry and Biology, University of Santiago de Chile, Av. Bernardo Ó Higgins 3363, Casilla 40, Correo 33, Estación Central, 9170022 Santiago, Chile. maialen.aldabaldetrecu@usach.cl.
Abstract:
The antibacterial effects against Staphylococcus epidermidis of five silver carboxylate complexes with anti-inflammatory ligands were studied in order to analyze and compare them in terms of stability (in solution and after exposure to UV light), and their antibacterial and morphological differences. Four effects of the Ag-complexes were evidenced by transmission electronic microscopy (TEM) and scanning electronic microscopy (SEM): DNA condensation, membrane disruption, shedding of cytoplasmic material and silver compound microcrystal penetration of bacteria. 5-Chlorosalicylic acid (5Cl) and sodium 4-aminosalicylate (4A) were the most effective ligands for synthesizing silver complexes with high levels of antibacterial activity. However, Ag-5Cl was the most stable against exposure UV light (365 nm). Cytotoxic effects were tested against two kinds of eukaryotic cells: murine fibroblast cells (T10 1/2) and human epithelial ovarian cancer cells (A2780). The main objective was to identify changes in their antibacterial properties associated with potential decomposition and the implications for clinical applications.
More Related Videos
Related Concept Videos
Complexation Equilibria: Factors Influencing Stability of Complexes
Substituent Effects on Acidity of Carboxylic Acids
Formation of Complex Ions
Nuclear Stability
To hold positively charged protons together...
RNA Stability
mRNA Stability and Gene Expression
Cis-acting Elements involved in mRNA stability


