The B-ADENOMA Study: Bowelscope - Accuracy of Detection using Endocuff Optimisation of Mucosal Abnormalities: Study...

Area of Science:

• Gastroenterology
• Oncology
• Public Health

Background:

• UK Bowel Cancer Screening (BowelScope) uses flexible sigmoidoscopy for patients aged 55 to reduce colorectal cancer incidence.
• Current adenoma detection rates (ADR) in BowelScope are low and variable, impacting its effectiveness.
• The Endocuff Vision device shows promise in increasing ADR, particularly in the left colon.

Purpose of the Study:

• To evaluate the efficacy of Endocuff-assisted flexible sigmoidoscopy in improving ADR within the BowelScope program.
• To compare ADR between Endocuff-assisted and standard flexible sigmoidoscopy in a screening population.
• To establish whether Endocuff Vision enhances adenoma detection in bowel cancer screening.

Main Methods:

• A prospective, multicenter, UK-based randomized controlled trial (RCT) comparing Endocuff-assisted versus standard flexible sigmoidoscopy.
• Recruitment of eligible patients aged 55-61 years invited for BowelScope screening.
• Randomization to Endocuff-assisted or standard procedure, stratified by age and sex, with data collection on ADR, comfort, and complications.

Main Results:

• The ADENOMA trial is designed to demonstrate a significant improvement in ADR with Endocuff Vision.
• Maximal benefit is anticipated in the left colon and in fecal occult blood test-positive screening patients.
• This trial is the first RCT to assess Endocuff Vision in bowel cancer screening flexible sigmoidoscopy.

Conclusions:

• The study aims to confirm if Endocuff Vision improves ADR in the BowelScope screening program.
• Enhanced ADR through Endocuff Vision could lead to increased colorectal cancer incidence reduction.
• Findings will inform potential improvements in quality indicators for screening sigmoidoscopy.