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Updated: Feb 8, 2026
08:42
A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis
Published on: April 10, 2019
8.2K
[Perinatal factors for necrotizing enterocolitis (NEC). A case-control study]
V Núñez Cerezo1, M Romo Muñoz1, J L Encinas1
1Servicio de Cirugía Pediátrica. Hospital Universitario La Paz. Madrid.
Summary
Infants experiencing fetal distress and early sepsis face increased risk of necrotizing enterocolitis (NEC). Antifungal treatments may also elevate NEC incidence, while antibiotics showed no significant risk.
Area of Science:
- Neonatalogy
- Perinatal Medicine
- Pediatric Surgery
Background:
- Necrotizing enterocolitis (NEC) is a severe gastrointestinal condition affecting premature infants.
- Identifying perinatal risk and protective factors is crucial for prevention and management.
Purpose of the Study:
- To investigate potential perinatal risk or protective factors associated with NEC in neonates.
Main Methods:
- Retrospective case-control study of 500 newborns (44 NEC cases, 456 controls) admitted to NICU from 2014-2015.
- Reviewed maternal and neonatal factors, including fetal distress, sepsis, birth weight, gestational age, catheterization, feeding times, and medication use.
- Matched cases and controls for analyzed factors; used parametric tests for statistical analysis (p < 0.05).
Main Results:
- No maternal risk factors for NEC were identified.
- Fetal distress and early sepsis were significantly associated with a higher risk of NEC (p < 0.0001).
- No statistical differences were found regarding enteral feeding timing or probiotic use.
Conclusions:
- Infants with a history of fetal distress and signs of early sepsis are at increased risk for NEC.
- Prophylactic antifungal treatment and orotracheal intubation may be associated with elevated NEC incidence.
- Antibiotic treatment did not demonstrate an increased risk of NEC.
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