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Non-invasive In Vivo Fluorescence Optical Imaging of Inflammatory MMP Activity Using an Activatable Fluorescent Imaging Agent

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Tumor-selective catalytic nanosystem for activatable theranostics.

Lu-Ying Duan¹, Yu-Jie Wang, Jin-Wen Liu

¹Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China. jinwenliu@hnu.edu.cn jianhuijiang@hnu.edu.cn.

Chemical Communications (Cambridge, England)

|July 7, 2018

Summary

This summary is machine-generated.

Researchers developed a novel nanosystem for targeted cancer treatment and imaging. This system utilizes chemodynamic therapy (CDT) and fluorescence imaging, specifically in tumors with high hydrogen peroxide levels.

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Published on: July 1, 2016

Area of Science:

Biomedical Engineering
Nanotechnology
Oncology

Background:

Tumor microenvironments are often characterized by high levels of hydrogen peroxide (H2O2).
Chemodynamic therapy (CDT) offers a promising approach for cancer treatment by utilizing reactive oxygen species (ROS).
Effective fluorescence imaging is crucial for monitoring therapeutic efficacy and tumor progression.

Purpose of the Study:

To develop a novel tumor-selective nanosystem for enhanced chemodynamic therapy (CDT).
To integrate activatable fluorescence imaging capabilities into the nanosystem.
To leverage the H2O2-rich tumor microenvironment for therapeutic activation.

Main Methods:

Design and synthesis of a catalytic nanosystem with tumor-targeting properties.
In vitro and in vivo evaluation of the nanosystem's H2O2-responsive catalytic activity.
Assessment of the nanosystem's fluorescence imaging performance in tumor models.

Main Results:

The developed nanosystem demonstrated high tumor selectivity and efficient catalytic activity in H2O2-rich environments.
Activatable fluorescence imaging allowed for real-time monitoring of the nanosystem's accumulation and therapeutic response.
Significant tumor growth inhibition was observed in preclinical models.

Conclusions:

The novel nanosystem provides an efficient platform for combined chemodynamic therapy and fluorescence imaging.
Its tumor-selectivity and responsiveness to the tumor microenvironment offer a promising strategy for cancer treatment.
This approach holds potential for improved diagnostics and therapeutics in oncology.