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Updated: Feb 8, 2026

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity
Published on: September 16, 2011
Drug Hypersensitivity due to Azathioprine with Elevated Procalcitonin
Tania Ahuja1, Frank R Chung2, Tania Ruiz-Maya3
1New York University Langone Health, Department of Pharmacy, 550 First Avenue, New York, NY 10016, USA.
Abstract:
We present a case of azathioprine hypersensitivity presenting as sepsis with elevated procalcitonin in a 68-year-old man with myasthenia gravis. The patient presented with fever, chills, nausea, vomiting, and headache. He developed numerous 1 cm erythematous papules over his upper torso. Infectious workup including bacteriological tests and microbial cultures was negative and a skin biopsy was performed which revealed suppurative folliculitis with eosinophils, consistent with drug hypersensitivity. Notably, acute phase reactants including C-reactive protein and procalcitonin were elevated upon presentation, likely secondary to drug hypersensitivity.
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