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Updated: Feb 8, 2026

Modeling Age-Associated Neurodegenerative Diseases in Caenorhabditis elegans
Published on: August 15, 2020
RNA stability and metabolism in regulated cell death, aging and diseases
Claudio Falcone1, Cristina Mazzoni1
1Pasteur Institute-Cenci Bolognetti Foundation, Department of Biology and Biotechnology "Charles Darwin", Sapienza University of Rome, Piazzale Aldo Moro 5, 00185-Rome, Italy.
Abstract:
The stability of RNAs represents a crucial point for cell life in that these molecules code for proteins and also play structural and regulatory functions. In this review, we will mainly focus on RNA stability and its connection with cell death and aging. In addition, we will consider the interaction of RNAs with ribonucleoprotein complexes, such as P-bodies and stress granules, as well as the role of non-coding RNAs. Finally, we will mention some correlations between RNA and diseases, considering yeast as a simple model system for the study of human cancer and neurodegenerative disorders.
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