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Primary myelofibrosis evolving to an aplastic appearing marrow
Jordan K Schaefer1, Sarah M Choi2, Gary D Luker3,4,5
1Division of Hematology/Oncology Department of Internal Medicine University of Michigan Ann Arbor MI USA.
Clinical Case Reports
|July 11, 2018
Summary
This case study shows a patient with primary myelofibrosis developed an unusual fatty bone marrow. Multiple biopsies and fat MRI confirmed this progressive fatty marrow transformation.
Area of Science:
- Hematology
- Oncology
- Radiology
Background:
- Primary myelofibrosis is a myeloproliferative neoplasm characterized by bone marrow fibrosis.
- Bone marrow fat content can change in various hematologic conditions.
Purpose of the Study:
- To describe a unique case of progressive fatty marrow transformation in primary myelofibrosis.
- To correlate bone marrow biopsy findings with advanced imaging techniques.
Main Methods:
- Serial bone marrow biopsies were performed.
- Quantitative fat magnetic resonance imaging (MRI) sequence was utilized.
Main Results:
- Bone marrow biopsies revealed an unusual, progressive fatty appearance over time.
- Quantitative fat MRI confirmed the increased marrow fat content, consistent with biopsy findings.
Conclusions:
- Progressive marrow fat accumulation can occur in primary myelofibrosis.
- Fat MRI is a valuable tool for assessing bone marrow composition changes in myelofibrosis.
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