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Rifaximin as a rare cause of rhabdomyolysis in cirrhosis

Alec B Rezigh1,2, Erin Armenia1,2, Ting Li1,2

  • 1Internal Medicine Presbyterian St. Lukes Medical Center Denver CO USA.

Clinical Case Reports
|July 11, 2018
PubMed

Insights

Rifaximin rarely causes rhabdomyolysis, a muscle-damaging condition. Always review patient medications, especially in cirrhotics, to identify potential drug-induced harm.

Area of Science:

  • Pharmacology
  • Hepatology
  • Toxicology

Background:

  • Rifaximin is a widely used antibiotic for hepatic encephalopathy.
  • Rhabdomyolysis is a serious condition involving muscle breakdown.

Observation:

  • This report details a rare case of rifaximin-induced rhabdomyolysis.
  • Exclusion of other causes was critical in identifying the drug as the etiology.

Findings:

  • Rhabdomyolysis is an infrequent adverse effect of rifaximin.
  • Medication review is essential for diagnosing drug-induced conditions, particularly in patients with liver disease.

Implications:

  • Clinicians should consider rifaximin as a potential cause of rhabdomyolysis.
  • Careful patient monitoring and medication review are crucial in managing patients with cirrhosis and hepatic encephalopathy.
Keywords:
adverse medication reactioncirrhosisrhabdomyolysisrifaximin

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