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Updated: Feb 7, 2026

Positron Emission Tomography Using 64-Copper as a Tracer for the Study of Copper-Related Disorders
Published on: April 28, 2023
Fluorogenic Sydnone-Modified Coumarins Switched-On by Copper-Free Click Chemistry
Camille Favre1,2, Frédéric Friscourt1,2
1Institut Européen de Chimie et Biologie , Université de Bordeaux , 2 rue Robert Escarpit , 33607 Pessac , France.
Abstract:
The synthesis, photophysical characterization, and biochemical application of sydnone-modified coumarins, a novel class of fluorogenic clickable reagents, are reported. The sydnone moiety, a stable aromatic 1,3-dipole, efficiently quenched the fluorescence of coumarin, which could be restored, with a 132-fold enhancement, upon cycloadditions with cyclooctynes, thereby expanding the fluorogenic click toolbox. TD-DFT calculations suggest that the fluorescence quenching of the sydnone-modified coumarins is likely due to the presence of an energetically low-lying nonemissive charge-separated state.
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