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Updated: Feb 7, 2026

Characterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test
Published on: November 13, 2016
The interrelation between FGF23 and glucose metabolism in humans
Stan R Ursem1, Marc G Vervloet2, Rahel M Büttler1
1Department of Clinical Chemistry, Endocrine Laboratory, VU University Medical Center, Amsterdam, the Netherlands.
A glucose load reduced Fibroblast Growth Factor 23 (FGF23) and phosphate levels in individuals with impaired glucose tolerance. However, FGF23 levels were unaffected by a hyperinsulinemic-euglycemic clamp or diet-induced changes.
Area of Science:
- Endocrinology
- Metabolic Research
- Bone Biology
Background:
- Fibroblast Growth Factor 23 (FGF23) is a hormone linked to glucose metabolism.
- Investigating the relationship between FGF23 and glucose homeostasis is crucial.
Purpose of the Study:
- To examine the impact of glucose load and hyperinsulinemic-euglycemic clamp on FGF23 levels.
- To determine the effect of diet-induced FGF23 changes on glucose and insulin concentrations.
Main Methods:
- Measured plasma FGF23 during oral glucose tolerance tests and hyperinsulinemic-euglycemic clamps.
- Assessed serum glucose and insulin after phosphate-modified diets.
Main Results:
- Oral glucose load decreased FGF23 and phosphate.
- Hyperinsulinemic-euglycemic clamp reduced phosphate but did not alter FGF23.
- Diet-induced FGF23 changes did not affect fasting glucose or insulin.
Conclusions:
- Glucose load rapidly alters FGF23 secretion in vitamin D deficient individuals with impaired glucose metabolism, independent of insulin.
- Dietary interventions increasing FGF23 do not impact fasting glucose or insulin levels.
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