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Epithelial Na+ Channel: Reciprocal Control by COMMD10 and Nedd4-2

Adam W Ware1, Tanya T Cheung1, Sahib Rasulov1

  • 1Department of Physiology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.

Frontiers in Physiology
|July 13, 2018
PubMed
Summary

COMMD10 protein regulates the epithelial sodium channel (ENaC) in kidney cells. Its absence disrupts ENaC function and blood pressure control by affecting protein trafficking and degradation.

Keywords:
ENaCkidneyprotein traffickingtransferrinubiquitin

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