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MOSAICISM AS A PROPOSED MECHANISM FOR ASYMMETRIC RETINAL TESSELLATIONS
Joseph J Raevis1, Ksenia Denisova, Elzbieta Mechel
1Department of Ophthalmology, SUNY Downstate Medical Center, Brooklyn, NY.
Retinal Cases & Brief Reports
|July 14, 2018
Summary
This study reports a rare case of significantly different retinal tessellation patterns between a patient's eyes. Mosaicism is proposed as a potential cause for this unusual ocular finding.
Area of Science:
- Ophthalmology
- Genetics
- Retinal Imaging
Background:
- Retinal tessellation, the pattern of choroidal vessels visible through the retinal pigment epithelium, is typically symmetric.
- Significant asymmetry in retinal tessellation is uncommon and often linked to conditions like asymmetric axial myopia or choroidal thinning.
Observation:
- A 59-year-old pseudophakic woman presented with markedly asymmetric retinal tessellation patterns in her eyes.
- Ocular coherence tomography and angiography revealed no significant asymmetrical choroidal thinning.
- Fluorescein angiography demonstrated hyperfluorescence correlating with tessellation patterns, particularly in the left eye.
Findings:
- This case represents the first documented instance of markedly asymmetric retinal tessellation without underlying causes such as asymmetric axial myopia or choroidal thinning.
- The observed asymmetry in retinal patterns was pronounced despite similar axial lengths and absence of significant choroidal abnormalities.
Implications:
- The findings suggest that mosaicism, a form of genetic variation where different cells within an individual have different genotypes, may be a contributing factor to asymmetric retinal tessellation.
- Further research into mosaicism could elucidate novel mechanisms behind variations in retinal structure and appearance.
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