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Activating Autophagy by Aerobic Exercise in Mice
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Autophagy in Hepatocytes during Distant Tumor Growth.

N P Bgatova1, S A Bakhbaeva2, Yu S Taskaeva2

  • 1Research Institute of Clinical and Experimental Lymphology, Branch of the Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia. n_bgatova@ngs.ru.

Bulletin of Experimental Biology and Medicine
|July 15, 2018
PubMed
Summary

Distant tumor growth triggers non-selective autophagy in mouse liver cells. This process, involving autophagosomes and lysosomes, helps maintain cellular and organismal homeostasis despite cancer development.

Keywords:
distant tumor growthimpaired structure of hepatocytesnon-selective autophagy

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Area of Science:

  • Hepatology
  • Cell Biology
  • Oncology

Background:

  • Hepatocarcinoma-29 is an experimental tumor model.
  • Distant tumor growth can impact organ function.
  • Liver homeostasis is crucial for overall health.

Purpose of the Study:

  • To investigate structural changes in mouse liver during experimental hepatocarcinoma growth.
  • To characterize the role of intracellular autophagy in this process.
  • To understand how liver cells maintain homeostasis under tumor burden.

Main Methods:

  • Electron microscopy was used to examine liver tissue.
  • Quantitative analysis of cellular components (cytoplasm, mitochondria, ER, lysosomes, lipids) was performed.
  • Stages of intracellular autophagy were identified and documented.

Main Results:

  • Hepatocarcinoma-29 growth led to decreased hepatocyte cytoplasm, mitochondria, ER, and lipid inclusions.
  • A significant increase in lysosomal structures was observed.
  • All stages of autophagy, including autophagosomes and autophagolysosomes, were present in hepatocytes.
  • Autophagosomes contained cytoplasmic fragments, glycogen, mitochondria, and ER fragments.

Conclusions:

  • Non-selective autophagy develops in the liver during distant tumor growth.
  • This autophagy is a mechanism to maintain intracellular homeostasis in hepatocytes.
  • Autophagy contributes to maintaining energy and trophic homeostasis of the organism.