Related Experiment Video
Updated: Feb 7, 2026
07:44
Author Spotlight: Implementation of BIVA for Analyzing Disease Risk Factors in Patients with Low Body Cell Mass
Published on: July 14, 2023
1.7K
Foot function in rheumatoid arthritis patients: a cross-sectional study
Agnes Patricia de Andrade1, Elinah Narumi Inoue1, Renato Nisihara2,3
1Rheumatology Service, Medicine Department, Evangelic University Hospital of Curitiba, R. Padre Agostinho, 2770, Curitiba, 80730-000, Brazil.
Clinical Rheumatology
|July 16, 2018
Summary
Rheumatoid arthritis (RA) patients frequently experience foot pain and functional difficulties, with 98% reporting pain. Controlling disease inflammation is key to managing these debilitating foot problems in RA.
Area of Science:
- Rheumatology
- Orthopedics
- Immunology
Background:
- Rheumatoid arthritis (RA) is a chronic autoimmune disease primarily affecting small joints.
- Foot involvement is common in RA, impacting patient function and quality of life.
Purpose of the Study:
- To determine the prevalence of foot problems in Brazilian RA patients.
- To investigate the relationship between foot involvement and disease activity markers, serological, and epidemiological factors.
Main Methods:
- A cross-sectional study involving 100 RA patients and 100 matched healthy controls.
- Foot function assessed using the Foot Functional Index-Brazilian version (FFI-BR).
- Disease activity measured by C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and DAS28-ESR.
Main Results:
- RA patients showed significantly higher rates of foot pain (98% vs 76%), functional difficulty (96% vs 66%), and incapacity (73% vs 20%) compared to controls.
- FFI-BR scores correlated significantly with ESR, CRP, and DAS28-ESR.
- No association found between FFI-BR scores and gender, ethnicity, rheumatoid factor status, or medication use.
Conclusions:
- The majority of RA patients suffer from significant foot problems.
- Foot involvement in RA is strongly associated with inflammatory biomarkers.
- Management of inflammatory activity may be crucial for improving foot health in RA patients.
Related Concept Videos
01:50Cross-Sectional Research
12.7K
In cross-sectional research, a researcher compares multiple segments of the population at the same time. If they were interested in people's dietary habits, the researcher might directly compare different groups of people by age. Instead of following a group of people for 20 years to see how their dietary habits changed from decade to decade, the researcher would study a group of 20-year-old individuals and compare them to a group of 30-year-old individuals and a group of 40-year-old...
12.7K
01:24Finding Volume Using Cross-Sectional Area
84
For solids whose cross-sectional areas vary in a predictable way, volume can be determined by integrating these areas along an axis perpendicular to the slices. This approach is particularly useful for polyhedral solids, where classical geometric formulas may not be immediately applicable. A tetrahedron provides a clear example of how cross-sectional integration can be applied to a three-dimensional object with continuously changing geometry.Consider a tetrahedron with height h and a base that...
84
01:26Profile Leveling and Cross Sections
1.7K
Profile leveling and cross-sections are surveying methods used to determine and document terrain elevations for infrastructure projects such as highways, railroads, canals, and pipelines. These methods provide data for earthwork planning and alignment of proposed routes. Profile leveling involves measuring elevations along a fixed line to create a vertical terrain profile. A surveyor sets up a leveling instrument at the benchmark (BM) and records a backsight (BS) to determine the...
1.7K
01:16Spinal Cord: Cross-sectional Anatomy
4.9K
The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
Gray Matter and its Components
Central to the gray matter is...
Gray Matter and its Components
Central to the gray matter is...
4.9K
01:28Muscles of the Leg that Move the Foot and Toes
4.1K
The human leg comprises an intricate system of muscles that facilitate the movement of feet and toes. Within this system, the muscles are categorized into the anterior, lateral, and posterior compartments, each with a unique set of muscles carrying out specific functions.
Anterior Compartment
The anterior compartment includes muscles that contribute to the dorsiflexion of the foot. This compartment houses the tibialis anterior, extensor hallucis longus, and extensor digitorum longus muscles....
Anterior Compartment
The anterior compartment includes muscles that contribute to the dorsiflexion of the foot. This compartment houses the tibialis anterior, extensor hallucis longus, and extensor digitorum longus muscles....
4.1K
01:34Crossing Over
172.2K
Unlike mitosis, meiosis aims for genetic diversity in its creation of haploid gametes. Dividing germ cells first begin this process in prophase I, where each chromosome—replicated in S phase—is now composed of two sister chromatids (identical copies) joined centrally.
The homologous pairs of sister chromosomes—one from the maternal and one from the paternal genome—then begin to align alongside each other lengthwise, matching corresponding DNA positions in a process...
The homologous pairs of sister chromosomes—one from the maternal and one from the paternal genome—then begin to align alongside each other lengthwise, matching corresponding DNA positions in a process...
172.2K