Related Experiment Video
Updated: Feb 7, 2026
05:53
Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
10.7K
Comorbidities and COPD severity in a clinic-based cohort
Chantal Raherison1,2,3, El-Hassane Ouaalaya4, Alain Bernady5
1Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, team EPICENE, UMR 1219, F-33000, Bordeaux, France. Chantal.raherison@chu-bordeaux.fr.
BMC Pulmonary Medicine
|July 18, 2018
Summary
Multimorbidity, the presence of multiple chronic conditions, is common in patients with Chronic Obstructive Pulmonary Disease (COPD). Specific comorbidity clusters are associated with more severe COPD symptoms and outcomes.
Area of Science:
- Pulmonology
- Internal Medicine
- Epidemiology
Background:
- Chronic Obstructive Pulmonary Disease (COPD) significantly contributes to global morbidity and mortality.
- Understanding the link between comorbidities and COPD severity is crucial for patient management.
Purpose of the Study:
- To investigate the association between specific comorbidities and the severity of Chronic Obstructive Pulmonary Disease (COPD).
Main Methods:
- A cohort of 1,584 COPD patients was analyzed using spirometry (FEV1/FVC < 70%) and a detailed web-based questionnaire.
- COPD severity was classified using GOLD 2011 guidelines.
- Principal component analysis and cluster analysis identified comorbidity phenotypes.
Main Results:
- Over 70% of COPD patients had at least one comorbidity.
- Patients in GOLD B and D severity groups had a significantly higher prevalence of two or more comorbidities (p < 0.001).
- Five distinct comorbidity clusters were identified, with clusters including cardiac issues, metabolic syndrome, apnea, anxiety-depression, malnutrition, osteoporosis, and bronchiectasis. These clusters were associated with symptomatic COPD (GOLD B and D).
Conclusions:
- Multimorbidity is highly prevalent in patients with Chronic Obstructive Pulmonary Disease (COPD).
- Specific comorbidity patterns are linked to increased symptom burden and disease severity in COPD patients.
Related Concept Videos
01:20COPD: Pathogenesis and Clinical Features
1.9K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.9K
01:26COPD: Management Using Bronchodilators and Corticosteroids
820
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
820
01:27Nursing Clinical Information System
1.3K
Nursing Clinical Information System (NCIS)
A Nursing Clinical Information System (NCIS) is a specialized type of healthcare information system tailored to meet the unique needs of nursing practice. It incorporates the principles of nursing informatics to streamline information management and improve the quality of care delivery.
Critical attributes of NCIS include:
A Nursing Clinical Information System (NCIS) is a specialized type of healthcare information system tailored to meet the unique needs of nursing practice. It incorporates the principles of nursing informatics to streamline information management and improve the quality of care delivery.
Critical attributes of NCIS include:
1.3K
01:16Clinical Trials
10.8K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
There are four phases in a clinical trial. A phase one...
10.8K
01:11Clinical Trials: Overview
5.0K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
5.0K
01:14Changes in Skin Color: Clinical Perspectives
3.7K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
3.7K