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Ervadivamines A and B, Two Unusual Trimeric Monoterpenoid Indole Alkaloids from Ervatamia divaricata
Zhi-Wen Liu1, Jian Zhang1,2, Song-Tao Li1
1Institute of Traditional Chinese Medicine and Natural Products, and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research , Jinan University , Guangzhou 510632 , P. R. China.
Abstract:
Ervadivamines A (1) and B (2), two unprecedented trimeric monoterpenoid indole alkaloids, were isolated from Ervatamia divaricata. They are the first examples of vobasine-iboga-vobasine-type alkaloid with both C-C and C-N linkage patterns. Their structures including absolute configurations were fully accomplished by extensive spectroscopic analysis, single-crystal X-ray diffraction, and electric circular dichroism methods. The plausible biogenetic pathways of these trimeric alkaloids were also proposed. In addition, compound 1 exhibited significant cytotoxicity against four cancer cells.
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