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Updated: Feb 7, 2026

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study
Published on: August 15, 2025
Differentiating Symptoms of Bipolar Disorder From Those of Temporal Lobe Epilepsy: A Case Report
Jennifer L Yehl1, Cory M Klippel, Alfred T Frontera
1YEHL, KLIPPEL: Department of Mental Health and Behavioral Sciences, James A. Haley Veterans' Hospital and Clinics, and Department of Psychiatry and Behavioral Sciences, University of South Florida, Tampa, FL FRONTERA: Department of Neurology, University of South Florida, and Department of Neurology, James A. Haley Veterans' Hospital and Clinics, Tampa, FL KOZEL: Department of Mental Health and Behavioral Sciences and HSR&D Center of Innovation on Disability and Rehabilitation Research (CINDRR), James A. Haley Veterans' Hospital and Clinics, and Department of Psychiatry and Behavioral Sciences, University of South Florida, Tampa, FL.
Abstract:
Bipolar I disorder and interictal personality syndrome have many overlapping characteristics that are difficult to distinguish. There is scant literature focused on interictal personality syndrome and no case reports to date detailing patients with comorbid bipolar pathology. We describe an individual with a history of bipolar I disorder who developed right temporal lobe epilepsy after several head injuries. He subsequently exhibited symptoms consistent with interictal personality syndrome that were independent of his bipolar symptomatology. Better understanding of these disorders can lead to improved diagnosis and symptom management. The similarities may also point to a partially shared neuropathology.
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