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Related Experiment Video

Updated: Feb 7, 2026

Robust Differentiation of Human iPSCs into a Pure Population of Adipocytes to Study Adipocyte-Associated Disorders

Robust Differentiation of Human iPSCs into a Pure Population of Adipocytes to Study Adipocyte-Associated Disorders

Published on: February 9, 2022

Pink Adipocytes.

Saverio Cinti¹

¹Department of Experimental and Clinical Medicine, Center of Obesity, University of Ancona (Politecnica delle Marche), Via Tronto 10a, 60020 Ancona, Italy.

Trends in Endocrinology and Metabolism: TEM

|July 19, 2018

Summary

This summary is machine-generated.

Adipocytes, versatile cells in adipose tissue, can transform between white, brown, and pink types. This plasticity allows adaptation to cold, energy balance, and pregnancy, highlighting dynamic cell roles.

Keywords:

adipocytes brown mammary gland pink transdifferentiation white

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Area of Science:

Cell biology
Physiology
Metabolism

Background:

Adipocytes are crucial for energy homeostasis, with distinct white and brown subtypes.
White adipocytes store lipids, while brown adipocytes generate heat through lipid burning.

Purpose of the Study:

To explore the dynamic plasticity and transdifferentiation capabilities of adipocytes.
To understand adipocyte roles in physiological adaptations like cold exposure and pregnancy.

Main Methods:

Review of existing literature and recent fate-mapping data.
Analysis of adipocyte behavior under various physiological conditions.

Main Results:

White adipocytes transdifferentiate into brown adipocytes during cold exposure.
Brown adipocytes convert to white adipocytes during positive energy balance.
Subcutaneous white adipocytes transform into 'pink' adipocytes during lactation.
Evidence suggests pink adipocytes can convert to brown adipocytes, and brown adipocytes to myoepithelial cells.

Conclusions:

Adipocyte plasticity is a key feature of adipose tissue, enabling adaptation to diverse physiological demands.
The interconversion of adipocyte subtypes underscores their dynamic nature and functional flexibility.