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Modulating receptor-ligand binding in biorecognition by setting surface wettability

Pilar Aragón1,2, Patricia Noguera1,2, María-José Bañuls1,2

  • 1Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València, Universitat de València, Camino de Vera s/n, 46022, Valencia, Spain.

Analytical and Bioanalytical Chemistry
|July 19, 2018
PubMed
Summary

Optimizing microarray biosensor surfaces with specific organosilanes significantly improves performance. Tailoring surface hydrophobicity, especially with fluorinated silanes, minimizes unwanted binding and enhances signal quality for better results.

Keywords:
BiosensingOrganosilaneProbe anchoringSurface wettabilityThiol-ene click reaction

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