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Updated: Feb 7, 2026

Culture and Imaging of Ex Vivo Organotypic Pseudomyxoma Peritonei Tumor Slices from Resected Human Tumor Specimens
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Culture and Imaging of Ex Vivo Organotypic Pseudomyxoma Peritonei Tumor Slices from Resected Human Tumor Specimens

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Pseudomyxoma peritonei with endometrial mucinous carcinoma and appendicular mucinous tumor: An unusual association

Eman Emam1,2, Ahmad Ghanim1,3, Ayman Ghanim1,4

  • 1Pathology Department, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.

Journal of Microscopy and Ultrastructure
|July 20, 2018
PubMed

Insights

Pseudomyxoma peritonei typically arises from appendicular or ovarian tumors. This case highlights an exceptional dual origin from both endometrial and appendicular mucinous tumors, emphasizing rare tumor associations.

Area of Science:

  • Oncology
  • Gastroenterology
  • Gynecologic Oncology

Background:

  • Pseudomyxoma peritonei (PMP) is a rare condition characterized by mucinous ascites.
  • PMP is most commonly associated with mucinous tumors of the appendix or ovary.
  • Associations with endometrial carcinoma are exceptionally rare.

Observation:

  • This report details a unique case of PMP with dual primary malignancies.
  • The identified primary sites were an appendicular mucinous tumor and an endometrial mucinous adenocarcinoma.
  • This dual primary presentation is exceedingly uncommon in the literature.

Findings:

  • The study confirms the possibility of PMP originating from multiple distinct mucinous carcinomas.
  • It underscores the diagnostic challenge in identifying the precise origin(s) of PMP.
  • The appendicular and endometrial origins represent a rare etiological combination for PMP.

Implications:

  • Clinicians should consider multiple primary sites when diagnosing PMP, especially in atypical cases.
  • Increased awareness of rare tumor associations like appendicular and endometrial origins is crucial for accurate diagnosis and management.
  • This case contributes to understanding the diverse origins of pseudomyxoma peritonei.
Keywords:
Appendicular adenocarcinomaPrimary mucinous endometrial carcinomaPseudomyxoma peritonei

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