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Updated: Feb 7, 2026
Contrast Enhanced Vessel Imaging using MicroCT
Published on: January 27, 2011
Coronary angiography using second-generation dual source computed tomography: Feasibility of low dose and low flow
Xiaomei Zhu1, Yusheng Yu, Dinghu Xu
1Radiological Department, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Department of Radiology, The Affiliated Jiangning Hospital of Nanjing Medical University, Jiangning District Department of Nuclear Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Abstract:
Improved contrast enhancement consistency can be achieved using an individualized contrast media (CM) protocol. This study aimed to assess the feasibility of a low-dose, low-flow rate CM protocol to achieve appropriate individual contrast enhancement using a newly advocated individualized test bolus-based protocol for second-generation dual-source computed tomography angiography.CM containing iodine (370 mg I/mL) was used in this study. A CM flow rate of 3.5 mL/s for patients with a body mass index (BMI) <25.0 kg/m, and 4.5 mL/s for those with BMI ≥25.0 kg/m was used in group 1 (n = 189). An individualized test-bolus based contrast injection protocol was then derived from the information gained from the test bolus and coronary enhancements in group 1. The proposed individualized test-bolus based CM injection protocol was applied in group 2 (n = 219). Ascending aortic attenuations (AAo) were measured and compared with both groups.The contrast enhancement consistency of AAo in group 2 improved significantly (31.8 vs 56.3 Hounsfield units [HU]; P < .001). The number of patients in group 2 with a contrast flow rate ≤3 mL/s was 63 (28.8%), with 77 (35.2%) using a contrast dose ≤40 mL. In group 2, no significant differences in mean AAo were found among subgroups with contrast flow rates ≤3.0, 3.1 to 4.0, 4.1 to 5.0 and >5.0 mL/s (351, 344, 346, and 348 HU, respectively), nor among subgroups with contrast doses ≤40, 41 to 50, 51 to 60, and >60 mL (349, 345, 344, and 350 HU, respectively).Improved individual contrast enhancement uniformity can be achieved using an individualized CM protocol tailored to a test bolus. Approximately, one-third of patients received CM at a flow rate of no more than 3 mL/s and a total dose of no more than 40 mL.
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