Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nephrons01:10

Nephrons

7.0K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
7.0K
Lineage Commitment01:21

Lineage Commitment

4.4K
Commitment is the  process whereby stem cells:
4.4K
Balancing Redox Equations02:58

Balancing Redox Equations

62.3K
Electrochemistry is the science involved in the interconversion of electrical and chemical reactions. Such reactions are called reduction-oxidation, or redox reactions. These important reactions are defined by changes in oxidation states for one or more reactant elements and include a subset of reactions involving the transfer of electrons between reactant species. Electrochemistry as a field has evolved to yield sufficient insights on the fundamental principles of redox chemistry and multiple...
62.3K
Equilibrium and Balance01:15

Equilibrium and Balance

6.7K
The inner ear assumes dual functionalities of auditory perception and equilibrium maintenance. The vestibule is the organ responsible for balance. This organ contains mechanoreceptors, specifically hair cells, endowed with stereocilia, which aid in deciphering information regarding the position and motion of our heads. Two intrinsic components, the utricle and saccule, help perceive head position, while the semicircular canals track head movement. Neurological messages initiated in the...
6.7K
Energy Balance01:19

Energy Balance

1.2K
The human body gets energy from the three macronutrients: carbohydrates, proteins, and fats. Energy is released when the chemical bonds in the organic compounds present in the food are broken down. The energy content of food is measured in kilocalories (kcal), defined as the amount of heat required to raise the temperature of one kilogram of water by one degree Celsius. This value is determined by measuring the temperature change of the water surrounding a calorimeter after the complete...
1.2K
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

4.0K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
4.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Innovative Technologies for Kidney Research: Three-Dimensional Imaging and Quantification.

Seminars in nephrology·2025
Same author

Feature-driven whole-tissue imaging with subcellular resolution.

Cell reports methods·2025
Same author

Somites are a source of nephron progenitors in zebrafish.

Nature communications·2025
Same author

Altered renal vascular patterning reduces ischemic kidney injury and limits age-associated vascular loss.

American journal of physiology. Renal physiology·2025
Same author

Feature-Driven Whole-Tissue Imaging with Subcellular Resolution.

bioRxiv : the preprint server for biology·2025
Same author

Enhancing kidney organoid maturity with inducible vascularization: another step forward for in vitro modeling.

Kidney international·2024
Same journal

Cilia and flagella - Current insights from diverse experimental systems.

Seminars in cell & developmental biology·2026
Same journal

Editorial for special issue "When should mathematical models be used in biology".

Seminars in cell & developmental biology·2026
Same journal

Conserved machinery, divergent functions: evolutionary plasticity of the STK36/ULK4 kinase complex in ciliogenesis and signaling.

Seminars in cell & developmental biology·2026
Same journal

Chemical biology tools for studying tissue development.

Seminars in cell & developmental biology·2026
Same journal

Tetrahymena as a model organism for cilia research.

Seminars in cell & developmental biology·2026
Same journal

Emerging Concepts in Cardiovascular Development and Regeneration.

Seminars in cell & developmental biology·2026
See all related articles

Related Experiment Video

Updated: Feb 7, 2026

Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors
12:03

Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors

Published on: July 8, 2012

19.3K

Nephron progenitor cell commitment: Striking the right balance.

Lori L O'Brien1

  • 1Department of Cell Biology and Physiology, UNC Kidney Center, University of North Carolina at Chapel Hill, 111 Mason Farm Road, Chapel Hill, NC, 27599, United States.

Seminars in Cell & Developmental Biology
|July 22, 2018
PubMed
Summary
This summary is machine-generated.

Kidney development relies on nephron progenitor cells (NPCs) that self-renew and differentiate. Maintaining a balance is crucial for sufficient nephron numbers, preventing kidney disease and hypertension.

Keywords:
DifferentiationNephrogenesisNephron progenitor cell (NPC)Self-renewal

More Related Videos

Estimation of Nephron Number in Whole Kidney using the Acid Maceration Method
08:15

Estimation of Nephron Number in Whole Kidney using the Acid Maceration Method

Published on: May 22, 2019

10.7K
Identification and Isolation of Oligopotent and Lineage-committed Myeloid Progenitors from Mouse Bone Marrow
07:21

Identification and Isolation of Oligopotent and Lineage-committed Myeloid Progenitors from Mouse Bone Marrow

Published on: July 29, 2018

9.5K

Related Experiment Videos

Last Updated: Feb 7, 2026

Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors
12:03

Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors

Published on: July 8, 2012

19.3K
Estimation of Nephron Number in Whole Kidney using the Acid Maceration Method
08:15

Estimation of Nephron Number in Whole Kidney using the Acid Maceration Method

Published on: May 22, 2019

10.7K
Identification and Isolation of Oligopotent and Lineage-committed Myeloid Progenitors from Mouse Bone Marrow
07:21

Identification and Isolation of Oligopotent and Lineage-committed Myeloid Progenitors from Mouse Bone Marrow

Published on: July 29, 2018

9.5K

Area of Science:

  • Nephrology and Developmental Biology
  • Cellular and Molecular Medicine

Background:

  • The kidney's filtering units, nephrons, originate from a single progenitor cell type.
  • Nephron progenitor cells (NPCs) are essential for forming the correct number of nephrons during development.
  • Insufficient nephron numbers are linked to serious health issues like hypertension and kidney disease.

Purpose of the Study:

  • To review the molecular mechanisms and signaling pathways governing nephron progenitor cell (NPC) maintenance.
  • To discuss the processes involved in NPC differentiation into mature nephron structures.
  • To highlight recent advancements in understanding NPC regulation and behavior during kidney development.

Main Methods:

  • Literature review of current research on kidney development and nephrogenesis.
  • Analysis of molecular and genetic studies investigating NPC behavior.
  • Synthesis of findings on the spatiotemporal dynamics of NPCs.

Main Results:

  • NPCs possess a critical self-renewal and differentiation balance.
  • Specific molecular signals and pathways regulate NPC fate decisions.
  • NPC behavior is dynamic in both space and time during kidney development.

Conclusions:

  • Understanding NPC regulation is key to addressing congenital kidney disorders.
  • Maintaining nephron endowment through balanced NPC activity is vital for long-term kidney health.
  • Future research directions include exploring novel therapeutic targets for kidney disease based on NPC biology.