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Updated: Feb 7, 2026

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
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PROGNOSTICATION OF CLINICAL OUTCOMES AFTER STEMI: THE ROLE OF VASCULAR ENDOTHELIAL GROWTH FACTOR-A

O Petyunina1, M Kopytsya1, I Kuznetsov1

  • 1Government institution "L.T. Malaya Therapy National Institute of the National Academy of medical science of Ukraine", Department of prevention and treatment of emergency conditions, Kharkiv; Kharkiv Medical Academy of Postgraduate Education, Department of cardiology and functional diagnostic Ukraine.

Georgian Medical News
|July 24, 2018
PubMed

Aim - to assess the role of Vascular endothelial growth factor-A (VEGF-A), which plays a key role in angiogenesis, in prognosis after myocardial infarction. 62 patients with ST-segment elevation myocardial infarction (STEMI), 51 (82.3%) male and 11 (17.7%) female at average age 58.63±8.90 years and 12 control group patients were enrolled to the study. Serum level of VEGF by enzyme-linked immunosorbent assay was determined. After a 6-month observation period afterinfarction angina were assessed. ROC-analysis revealed cut-off level of VEGF-A ≤172.4 pg/ml was determined on the 7th day of STEMI, which had became predictor of repeated coronary events after the 6-month observation period (AUC 0.697, sensitivity was 88,9% and specificity - 50.9%; 95% CІ 0.567-0.807, Р=0.0515). Multivariate logistic analysis determined that anxiety and depression were assessed with Taylor and HADS questionnaire associated with VEGF-A decrease in patients with STEMI (anxiety: OR 0.834, 95% CІ 0.726 - 0.959, Р=0.0107; depression: OR 0.741, 95% CІ 0.535 - 1.027, Р=0.0519. Anxiety and depression influenced on serum VEGF-A level decrease which indicates the lack of myocardial neovascularization after STEMI and makes a contribution to postinfarction angina development.

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