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Updated: Feb 7, 2026
Back Mechanical Sensitivity Assessment in the Rat for Mechanistic Investigation of Chronic Back Pain
Published on: August 30, 2022
[CORRELATION BETWEEN MECHANICAL PAIN SENSITIVITY DEGREE AND MOR PROTEIN CONCENTRATION OVER VARIOUS PHASES OF THE
M Apkhazava1, I Kvachadze1, M Tsagareli1
1Tbilisi State Medical University, Department of Physiology, Georgia.
Abstract:
The large number of studies occurred in recent decades show the effect of sex hormones on pain sensitivity and response to analgesics. The purpose of current study was to assess the correlation between the mechanical pain sensitivity degree and the dynamics of the μ-opioid receptor protein (MOR) concentration, also to investigate the correlation of sex hormones levels with the degree of mechanical pain sensitivity and the dynamics of MOR concentration. A decreased mechanical pressure threshold, mechanical pain threshold and mechanical pain tolerance have been revealed in the luteal phase of the OMC. The study found the relation of mechanical pain sensitivity decrease degree in the luteal phase of OMC on the dynamics of MOR concentration's variation (increase /decrease). The study also revealed the correlation between the indices of mechanical pain sensitivity and the concentration of follicle-stimulating hormone in the follicular phase of OMC, as well as the correlation between the indices of mechanical pain sensitivity, progesterone and MOR concentrations in the luteal phase of OMC. The relationship between the mechanical pain sensitivity degree, also the MOR concentration andprolactinorluteinizing hormone levels was not found.
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