CO-ADMINISTRATION OF LIVE PROBIOTICS WITH CHONDROPROTECTOR IN MANAGEMENT OF EXPERIMENTAL KNEE OSTEOARTHRITIS

The aim of the study was to study the therapeutic effect of the chondroprotector and live probiotic culture on the repair of cartilage tissue of the knee joint of rats during monoiodoacetate-induced osteoarthritis. The study used 90 white male Wistar rats weighing 180-240 g, which were randomly diluted into nine groups of 10 animals each, with double control and taking into account the intact group. The animals of the therapeutic groups received the chondroprotector and the probiotic separately and alongside. Joint removing and sample preparation were carried out on the 30th day of the experiment. Histological findings of cartilage tissue of the knee joint in positive control groups did not differ from intact. Experimental osteoarthritis caused significant changes in the histoarchitectonics of the cartilaginous tissue, dystrophy of the intercellular substance, fibrosis on the cartilage surface. A separate application of the chondroprotector and probiotic had a positive effect on the prevention of cartilage destruction. Their joint administration had the most significant effect, confirming the hypothesis of the summation of the effect of drugs. Thus, the use of the chondroprotector enhances the positive effect of the probiotic microbiota in anti-inflammatory processes.