Related Experiment Video
Updated: Feb 7, 2026
06:10
Real-Time Imaging of CCL5-Induced Migration of Periosteal Skeletal Stem Cells in Mice
Published on: September 16, 2020
2.6K
Bone Scintigraphy in Poststreptococcal Periostitis With Dysproteinemia.
Sophie Bourgeois1, Willy Peetermans2, Nathalie Noppe3
1From the Departments of Nuclear Medicine and Molecular Medicine.
Clinical Nuclear Medicine
|July 24, 2018
Summary
Goldbloom syndrome, a rare bone disorder, was diagnosed in an adult patient presenting with severe bone pain. This case expands the known age range for this condition, previously thought to affect only children and adolescents.
Area of Science:
- Medical Case Study
- Rheumatology
- Pediatric Endocrinology
Background:
- Goldbloom syndrome is characterized by idiopathic periosteal hyperostosis.
- It is typically associated with dysproteinemia and elevated inflammatory parameters.
- Previously, this condition was exclusively documented in pediatric and adolescent populations.
Observation:
- A 39-year-old man experienced severe bone pain in his tibiae and forearms.
- Symptoms emerged four months after a poststreptococcal sepsis, which included pneumonia and erysipelas.
- Bone scintigraphy revealed bilateral periostitis of the tibia, ulna, and radius.
Findings:
- The patient exhibited increased inflammatory parameters and dysproteinemia.
- These clinical and biochemical findings, alongside imaging results, led to the diagnosis of Goldbloom syndrome.
- This represents a rare adult case of a condition traditionally seen in younger individuals.
Implications:
- This case challenges the established age demographic for Goldbloom syndrome.
- It suggests that adult patients presenting with similar clinical and biochemical profiles should be evaluated for this condition.
- Further research may be warranted to understand the pathophysiology and prevalence of Goldbloom syndrome in adults.
Related Concept Videos
01:25Imaging Studies II: Positron Emission Tomography and Scintigraphy
606
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
Fundamental Principles of PET
606
01:55Bone Structure
51.8K
Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
51.8K
01:40Bone Remodeling
40.5K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.5K
01:27Compact Bone
16.6K
Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
16.6K
01:29Bone Disorders
5.4K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.4K
01:12The Hyoid Bone
5.2K
The hyoid bone is a small U-shaped bone located in the upper neck at the level of the inferior mandible, with its tips pointing posteriorly. It does not directly articulate with any other bone in the body. The hyoid acts as the attachment site for the tongue, the larynx, and the pharynx. It is held in position by a series of small muscles attached from above or below. These muscles help to move the hyoid up/down or forward/back in coordination with movements of the tongue, larynx, and pharynx...
5.2K