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Updated: Feb 7, 2026

In vivo Imaging and Therapeutic Treatments in an Orthotopic Mouse Model of Ovarian Cancer
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SWI/SNF Complexes in Ovarian Cancer: Mechanistic Insights and Therapeutic Implications

Takeshi Fukumoto1, Elizabeth Magno1, Rugang Zhang2

  • 1Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania.

Molecular Cancer Research : MCR
|July 25, 2018
PubMed

Insights

SWI/SNF chromatin remodeling complexes are altered in ovarian cancer, particularly ARID1A mutations in clear cell subtypes. Understanding these alterations aids developing targeted ovarian cancer therapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Ovarian cancer is a lethal gynecologic malignancy with limited therapeutic options.
  • SWI/SNF chromatin remodeling complexes are frequently altered in various cancers, including ovarian cancer.
  • Specific SWI/SNF alterations vary by histologic subtype, impacting disease mechanisms.

Purpose of the Study:

  • To review recent advancements in understanding SWI/SNF alterations in ovarian cancer.
  • To focus on specific SWI/SNF alterations (ARID1A, SMARCA4, CARM1) in distinct ovarian cancer subtypes.
  • To explore how these insights can inform personalized therapeutic strategies.

Main Methods:

  • Literature review of recent progress in SWI/SNF alterations in ovarian cancer.
  • Focus on genetic alterations (mutation, amplification/upregulation) in specific genes.
  • Analysis of SWI/SNF complex roles in different ovarian cancer histologic subtypes.

Main Results:

  • ARID1A mutations are prevalent in endometriosis-associated clear cell and endometrioid ovarian cancers.
  • SMARCA4 mutations are associated with small cell carcinoma of the ovary, hypercalcemic type.
  • CARM1 amplification/upregulation is observed in high-grade serous ovarian cancer, affecting BAF155.

Conclusions:

  • SWI/SNF alterations provide mechanistic insights into ovarian cancer development across subtypes.
  • Understanding these molecular underpinnings is crucial for developing targeted therapies.
  • Personalized therapeutic strategies can be developed based on specific SWI/SNF alterations.

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