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Related Experiment Video

Updated: Feb 7, 2026

Deep Brain Stimulation with Simultaneous fMRI in Rodents
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Resting State fMRI in Rodents.

Wen-Ju Pan1, Jacob Billings2, Maysam Nezafati1

  • 1Biomedical Engineering, Emory University/Georgia Institute of Technology, Atlanta, Georgia.

Current Protocols in Neuroscience
|July 25, 2018
PubMed
Summary
This summary is machine-generated.

This study details a resting-state functional magnetic resonance imaging (fMRI) protocol for rats. This method enables the study of brain networks in animal models, aiding translational research in neurological disorders.

Keywords:
MRIfunctional connectivityratresting state fMRI

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Area of Science:

  • Neuroscience
  • Functional Neuroimaging
  • Animal Models

Background:

  • Resting-state functional magnetic resonance imaging (fMRI) and functional connectivity analysis are crucial tools for understanding brain networks in humans.
  • Applying these techniques in rodents offers translational insights into brain disorders and detailed neurophysiological examination.

Purpose of the Study:

  • To describe a comprehensive protocol for resting-state functional connectivity analysis in anesthetized rats.
  • To provide a framework for researchers aiming to utilize rodent models for brain network studies.

Main Methods:

  • Detailed protocol for animal setup and preparation for resting-state fMRI in rats.
  • Guidelines for data acquisition using fMRI in anesthetized rodents.
  • Overview of potential data analysis pipelines for functional connectivity.

Main Results:

  • A standardized protocol for resting-state fMRI in rats was established.
  • The protocol covers the entire workflow from animal handling to data analysis.
  • This facilitates reproducible and reliable functional connectivity studies in rodent models.

Conclusions:

  • The described protocol enables robust resting-state functional connectivity measurements in rats.
  • This approach supports translational neuroscience research by bridging human and rodent brain studies.
  • It provides a foundation for investigating brain network dynamics in health and disease using rodent models.