Time-Varying Directed Interactions in Functional Brain Networks: Modeling and Validation

Understanding the dynamic nature of brain connectivity is critical for elucidating neural processing, behavior, and brain disorders. Traditional approaches such as sliding-window correlation (SWC) characterize time-varying undirected associations but do not resolve directional interactions, limiting inference about time-resolved information flow in brain networks. We introduce sliding-window prediction correlation (SWpC), which embeds a directional linear time-invariant (LTI) model within each sliding window to estimate time-varying directed functional connectivity (FC). SWpC yields two complementary descriptors of directed interactions: a strength measure (prediction correlation) and a duration measure (window-wise duration of information transfer). Using concurrent local field potential (LFP) and fMRI BOLD recordings from rat somatosensory cortices, we demonstrate stable directionality estimates in both LFP band-limited power and BOLD. Using Human Connectome Project (HCP) motor task fMRI, SWpC detects significant task-evoked changes in directed FC strength and duration and shows higher sensitivity than SWC for identifying task-evoked connectivity differences. Finally, in post-concussion vestibular dysfunction (PCVD), SWpC reveals reproducible vestibular-multisensory brain-state shifts and improves healthy-control vs subacute patient (HC-ST) discrimination using state-derived features. Together, these results show that SWpC provides biologically interpretable, time-resolved directed connectivity patterns across multimodal validation and clinical application settings, supporting both basic and translational neuroscience.