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Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies
Published on: August 11, 2023
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Zinc, Copper, and Iron in Oral Submucous Fibrosis: A Meta-Analysis
Prageet K Sachdev1, Jeanne Freeland-Graves1, S Natasha Beretvas2
1Department of Nutritional Sciences, College of Natural Sciences, The University of Texas at Austin, 103 W. 24th St. A2703, Austin, TX 78712, USA.
International Journal of Dentistry
|July 27, 2018
Summary
This meta-analysis found altered levels of trace elements in oral submucous fibrosis (OSF). Copper levels were higher, while zinc and iron levels were lower in OSF patients, suggesting their potential as diagnostic biomarkers.
Area of Science:
- Oral pathology
- Trace element metabolism
- Biomarker discovery
Background:
- Oral submucous fibrosis (OSF) is a potentially malignant oral disorder characterized by fibrosis and inflammation.
- Previous studies on trace element levels in OSF patients have yielded inconsistent findings.
- Understanding these alterations is crucial for improving diagnostic and prognostic capabilities.
Purpose of the Study:
- To conduct a meta-analysis of studies reporting zinc (Zn), copper (Cu), and iron (Fe) levels in patients with and without OSF.
- To systematically evaluate the association between OSF and the levels of these key trace elements.
- To determine the potential of Zn, Cu, and Fe as biomarkers for OSF.
Main Methods:
- Comprehensive literature search of Embase, PubMed, Cochrane Library, and Web of Science databases up to January 2017.
- Inclusion of 34 relevant reports for meta-analysis.
- Utilized standardized mean difference as the effect size and robust variance estimation to handle dependent outcomes.
Main Results:
- Significant increase in copper (Cu) levels in OSF patients (effect size = 1.17, p < 0.05).
- Significant decrease in zinc (Zn) levels in OSF patients (effect size = -1.95, p < 0.05).
- Significant decrease in iron (Fe) levels in OSF patients (effect size = -2.77, p < 0.01).
Conclusions:
- Altered levels of zinc, copper, and iron are significantly associated with oral submucous fibrosis.
- These trace elements show potential as additional biomarkers for the diagnosis and prognosis of OSF.
- Further research can validate the clinical utility of these biomarkers in managing OSF.
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