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Updated: Feb 7, 2026

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome
Published on: October 3, 2018
Monosomy 7 in Pediatric Myelodysplastic Syndromes
Marcin W Wlodarski1, Sushree S Sahoo2, Charlotte M Niemeyer3
1Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Faculty of Medicine, Medical Center, University of Freiburg, Mathildenstr.1, Freiburg 79106, Germany; German Cancer Consortium (DKTK), Freiburg, Germany; Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Abstract:
Myelodysplastic syndromes (MDS) in children and adolescents are a rare heterogeneous group of clonal stem cell disorders. Complete or partial loss of chromosome 7 constitutes the most common cytogenetic abnormality encountered in any type of childhood MDS, is associated with more advanced disease, and usually requires a timely allogeneic stem cell transplantation. This article provides insights into the current understanding of the genotype, phenotype, and clonal evolution patterns in pediatric MDS associated with loss of chromosome 7.
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