Optimization and characterization of deoxypodophyllotoxin loaded mPEG-PDLLA micelles by central composite design with

Ying-Lan Yu1, Ya-Nan Li1, Yong Zhang2

  • 1Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.

Related Concept Videos

Response Surface Methodology01:16

Response Surface Methodology

Response Surface Methodology (RSM) is a collection of statistical and mathematical techniques used to develop, improve, and optimize processes. It is particularly valuable when many input variables or factors potentially influence a response variable.
The process of RSM involves several key steps:
668
Design of Columns under a Centric Load01:17

Design of Columns under a Centric Load

The design of columns under centric load is a fundamental aspect of structural engineering and is critical for ensuring the stability and integrity of structures. Euler's and Secant's formulas are central to understanding and calculating the critical load and deformation behaviors of columns, providing a basis for safe and effective structural design.
Euler's formula is applicable under the assumption that the column is a perfect, straight, homogenous prism, and it is operating...
565
Design of Columns under an Eccentric Load01:21

Design of Columns under an Eccentric Load

Designing columns to withstand eccentric loads is a critical aspect of structural engineering, ensuring structures can support off-center loads without failure. This design process must account for the additional normal stresses introduced by eccentric loading, which can significantly influence a column's stress distribution and overall stability. An eccentric load applied to a column induces normal stresses that can be conceptualized as a combination of stresses due to an equivalent...
1.2K
Design Example: Frog Muscle Response01:14

Design Example: Frog Muscle Response

A student is tasked to work on an intriguing experiment involving an RL (Resistor-Inductor) circuit to study the muscle response of a frog's leg to electrical stimulation. The RL circuit plays a crucial role in this experiment, providing the means to control and measure the electrical impulses that trigger muscle contraction.
When the switch connecting the RL circuit is closed, a brief muscle contraction is observed. This is because, at a steady state, the inductor acts like a short...
606
Factorial Design02:01

Factorial Design

Factorial Analysis is an experimental design that applies Analysis of Variance (ANOVA) statistical procedures to examine a change in a dependent variable due to more than one independent variable, also known as factors. Changes in worker productivity can be reasoned, for example, to be influenced by salary and other conditions, such as skill level. One way to test this hypothesis is by categorizing salary into three levels (low, moderate, and high) and skills sets into two levels (entry level...
14.0K
Classifying Matter by Composition03:35

Classifying Matter by Composition

Matter: Pure Substances and Mixtures
According to its composition, the matter can be classified into two broad categories — pure substances and mixtures. 
A pure substance is a form of matter that has a constant composition throughout with uniform properties. For example, any sample of sucrose has the same composition and same physical properties, such as melting point, color, and sweetness, regardless of the source from which it is isolated. 
A mixture is composed of two or...
90.7K