Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

1.6K
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
1.6K
Higher Mental Functions of Brain: Learning and Memory01:26

Higher Mental Functions of Brain: Learning and Memory

2.1K
Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or...
2.1K
Retrieval01:12

Retrieval

450
Retrieval is the process of getting information out of memory storage and back into conscious awareness. This ability is essential for daily tasks like brushing hair and teeth, driving to work, and performing job duties. Retrieval occurs in three ways: recall, recognition, and relearning.
Recall involves accessing information without cues, such as during an essay test, where individuals must retrieve facts and concepts from memory unaided. Another example is remembering the name of a colleague...
450
ER Retrieval Pathway01:45

ER Retrieval Pathway

4.8K
In the secretory pathway, vesicles transport proteins from one cellular compartment to another in forward transport to deliver the protein to its correct location. Occasionally, misfolded proteins and incorrect proteins escape their original compartments, and a retrieval pathway is used to return the escaped proteins to their original compartment.
The ER uses many checkpoints to prevent the entry of incorrectly folded or a resident protein as cargo onto a transport vesicle. These mechanisms...
4.8K
Binet's Contribution to Measures of Intelligence01:23

Binet's Contribution to Measures of Intelligence

1.7K
Alfred Binet, along with his student Théophile Simon, was tasked by the French Ministry of Education in 1904 to create a method for identifying students who struggled to learn through conventional classroom instruction. This initiative aimed to address overcrowding by placing such students in specialized schools. Binet and Simon developed an intelligence test comprising 30 tasks, ranging from simple commands, like touching one's nose or ear, to more complex tasks, such as drawing...
1.7K
Critical Region, Critical Values and Significance Level01:16

Critical Region, Critical Values and Significance Level

13.4K
The critical region, critical value, and significance level are interdependent concepts crucial in hypothesis testing.
In hypothesis testing, a sample statistic is converted to a test statistic using z, t, or chi-square distribution. A critical region is an area under the curve in  probability distributions demarcated by the critical value. When the test statistic falls in this region, it suggests that the null hypothesis must be rejected. As this region contains all those values of the...
13.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Competitive interactions shape mammalian brain network dynamics and computation.

Nature neuroscience·2026
Same author

PET imaging utility of a novel Aβ-tracking PET radiotracer, [<sup>18</sup>F]FC119S in aged vervet monkeys.

Journal of translational medicine·2026
Same author

Basic Science and Pathogenesis.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

The prefrontal operculum, a human-specific hub for the cognitive control of speech.

Communications biology·2025
Same author

Age, glucose tolerance, and cognitive performance in female vervet monkeys.

GeroScience·2025
Same author

Correction: Short- and long-term modulation of rat prefrontal cortical activity following single doses of psilocybin.

Molecular psychiatry·2025
Same journal

Does stimulus preceding negativity reflect predictions in a somatosensory roving paradigm?

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

Temporal Dynamics of EEG Reflect Continuous Error Correction During Force Control.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

Frontoparietal Hub Connectivity Integrates Information from Multiple Sources.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

Mapping the Heart-Brain Continuum beyond Heart Failure: Why Neurology Matters.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

Emergence of behavioral tinnitus in gerbils is associated with reduced spontaneous rates in single auditory nerve fibers.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

Decoding the neural stages from action and object recognition to mentalizing.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
See all related articles

Related Experiment Video

Updated: Feb 7, 2026

A Pilot Study on the Repetitive Transcranial Magnetic Stimulation of A&#946; and Tau Levels in Rhesus Monkey Cerebrospinal Fluid
06:22

A Pilot Study on the Repetitive Transcranial Magnetic Stimulation of Aβ and Tau Levels in Rhesus Monkey Cerebrospinal Fluid

Published on: September 3, 2021

4.1K

The Rhesus Monkey Hippocampus Critically Contributes to Scene Memory Retrieval, But Not New Learning.

Sean Froudist-Walsh1, Philip G F Browning1, Paula L Croxson1

  • 1Glickenhaus Laboratory of Neuropsychology, Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029 and.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|July 28, 2018
PubMed
Summary
This summary is machine-generated.

Precise hippocampal lesions in monkeys impaired recall of past visual memories equally, regardless of age. However, these monkeys could still learn new visual information, suggesting the hippocampus is crucial for memory retrieval but not new learning after damage.

Keywords:
anterograde amnesiaepisodicmacaquememoryretrograde amnesiarhesus

More Related Videos

Drosophila Courtship Conditioning As a Measure of Learning and Memory
09:29

Drosophila Courtship Conditioning As a Measure of Learning and Memory

Published on: June 5, 2017

19.2K
Reversible Cooling-induced Deactivations to Study Cortical Contributions to Obstacle Memory in the Walking Cat
09:43

Reversible Cooling-induced Deactivations to Study Cortical Contributions to Obstacle Memory in the Walking Cat

Published on: December 11, 2017

7.3K

Related Experiment Videos

Last Updated: Feb 7, 2026

A Pilot Study on the Repetitive Transcranial Magnetic Stimulation of A&#946; and Tau Levels in Rhesus Monkey Cerebrospinal Fluid
06:22

A Pilot Study on the Repetitive Transcranial Magnetic Stimulation of Aβ and Tau Levels in Rhesus Monkey Cerebrospinal Fluid

Published on: September 3, 2021

4.1K
Drosophila Courtship Conditioning As a Measure of Learning and Memory
09:29

Drosophila Courtship Conditioning As a Measure of Learning and Memory

Published on: June 5, 2017

19.2K
Reversible Cooling-induced Deactivations to Study Cortical Contributions to Obstacle Memory in the Walking Cat
09:43

Reversible Cooling-induced Deactivations to Study Cortical Contributions to Obstacle Memory in the Walking Cat

Published on: December 11, 2017

7.3K

Area of Science:

  • Neuroscience
  • Cognitive Science
  • Primate Models

Background:

  • The hippocampus is critical for memory, but its precise role in retrieving multiple, sequentially encoded memories after damage remains unclear.
  • Human amnesia studies are limited by imprecise lesions, while rodent models may not fully capture complex memory processes.
  • Existing research shows conflicting results regarding temporal gradients in hippocampal amnesia.

Purpose of the Study:

  • To investigate the effect of precise hippocampal lesions on the retrieval of multiple, sequentially encoded visual memories in nonhuman primates.
  • To determine if hippocampal damage causes temporally graded or ungraded amnesia for previously learned visual object-in-place scenes.
  • To assess the impact of hippocampal lesions on the acquisition of new visual memories.

Main Methods:

  • Bilateral neurotoxic hippocampal lesions were induced in adult rhesus monkeys.
  • Control group consisted of unoperated monkeys.
  • Both groups were tested on recognition of previously learned visual object-in-place scenes and on learning new scenes.

Main Results:

  • Monkeys with hippocampal lesions were significantly impaired in recognizing scenes encoded before the lesion.
  • No temporal gradient was observed; recent and remote memories were equally affected.
  • Hippocampal lesions did not impair the ability to learn new visual scenes.

Conclusions:

  • The hippocampus is vital for the retrieval of complex visual memories, irrespective of their age, in primates.
  • The hippocampus may be involved in memory acquisition and storage, but its function in new learning can be compensated by other brain regions.
  • These findings highlight the utility of nonhuman primate models for studying amnesia and memory consolidation.