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Updated: Feb 7, 2026

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity
Published on: September 16, 2011
Use of Alternative Antiplatelet Agents for Clopidogrel Hypersensitivity
Ayesha Ather1, Craig J Beavers1
1Department of Pharmacy Services, UK Healthcare, University of Kentucky College of Pharmacy, Lexington, KY 40536, United States.
Abstract:
Clopidogrel is a widely used agent for secondary prevention of vascular events and is a cornerstone of dual antiplatelet therapy in patients with acute coronary syndrome (ACS) post coronary stent implantation. Hypersensitivity reactions to clopidogrel are well documented and may range from localized to systemic in presentation. This can lead to discontinuation of therapy, thus increasing the risk of vascular events. The authors have developed recommendations for potential alternative agents for the management of clopidogrel hypersensitivity reactions. Proposed strategies include treatment with an alternative P2Y12 inhibitor, cilostazol or warfarin.
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