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Updated: Feb 7, 2026
Measuring Uptake of the Glucose Analog, 6-(N-(7-Nitrobenz-2-Oxa-1,3-Diazol-4-yl)Amino)-6-Deoxyglucose, in Intact Murine Neural Retina
Published on: March 14, 2025
Synthesis of 6-SF5-indazoles and an SF5-analog of gamendazole
Oleksandr S Kanishchev1, William R Dolbier
1Department of Chemistry, PO Box 117200, University of Florida, Gainesville, FL 32611-7200, USA. wrd@chem.ufl.edu.
Abstract:
This work describes an efficient synthetic approach for a new type of SF5-substituted heterocyclic system, namely 6-SF5-indazoles. During this study, various derivatives of 6-SF5-indazoles such as bromo, iodo, nitro, N-acetyl and N-benzyl substituted compounds were synthesized and characterized. In addition, the utility of the synthetic methodology was demonstrated via the synthesis of 6-SF5-gamendazole - a fully matched analog of the experimental male contraceptive gamendazole, which has a 6-CF3-substituted indazole core.
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