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Updated: Apr 2, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Synthesis of Reagent FCH2CF2SO2Na: A Source of the FCH2CF2• Radical and Useful for Introduction of the -SCF2CH2F
Satyajit Majumder1, Md Nirshad Alam1, Teruo Umemoto1
1Department of Chemistry, University of Florida, Gainesville, Florida 32611-7011, United States.
Abstract:
Methods for the direct 1,1,2-trifluoroethylation of molecules via oxidative or visible light photoredox radical generating processes are rare, as is chemistry for electrophilic 1,1,2-trifluoroethylthiolaton. Here, we report the preparation of a benchtop stable reagent, sodium 1,1,2-trifluoroethanesulphinate, that functions to introduce such groups into a broad variety of electron deficient and electron rich heteroaromatic and unactivated alkene systems, using oxidative processes to generate the 1,1,2-trifluoroethyl radical and the reagent PCl3 to introduce the 1,1,2-trifluoroethylthio group.
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