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Palladium-Catalyzed N-Arylation of Sulfoximines with Aryl Sulfonates
Qingjing Yang1, Pui Ying Choy2, Qingyang Zhao2
1The Hong Kong Polytechnic University Shenzhen Research Institute (SZRI) , Shenzhen 518057 , P. R. China.
Abstract:
Palladium-catalyzed C-N bond coupling reaction between NH-sulfoximines and aryl halides (e.g., -Br, -I, and -Cl and pseudohalides -OTf and -ONf) was successfully achieved. Nevertheless, aryl tosylates/mesylates left much to be achieved. In this report, a general N-arylation of sulfoximines with aryl sulfonates is described. Using Pd(OAc)2/MeO-CM-phos complex, the N-aryl sulfoximine products can be obtained in good-to-excellent yields (up to 99%) with good common functional group compatibility. In addition to arene moieties, alkenyl tosylates are shown to be successful coupling partners.
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