Gas-Generating Nanoplatforms: Material Chemistry, Multifunctionality, and Gas Therapy

Area of Science:

• Nanomedicine
• Theranostics
• Gas Therapy

Background:

• Theranostic nanomedicine advances enable functional nanoplatforms for biomedical uses.
• Gas-generating nanoplatforms (GGNs) are emerging for diverse gas therapies.
• GGNs utilize therapeutic gases (O2, NO, CO, H2, H2S, SO2) and supplementary gases (CO2, DLM, PFC).

Purpose of the Study:

• To review recent developments in GGN design and construction for efficient gas therapies.
• To explore GGNs triggered by exogenous physical stimuli or endogenous disease-environment responsiveness.
• To discuss the application of GGNs in diagnostic imaging and therapeutic interventions.

Main Methods:

• Review of literature on rational design and chemical construction of GGNs.
• Analysis of various nanocarriers used for gas delivery (e.g., PLGA, micelles, silica, MnO2, graphene).
• Examination of GGN applications in biomedical fields.

Main Results:

• GGNs are successfully developed using diverse nanocarriers for targeted gas delivery.
• GGNs demonstrate potential in both diagnostic imaging and therapeutic applications.
• Various therapeutic and supplementary gases can be generated and delivered by GGNs.

Conclusions:

• GGNs represent a promising theranostic strategy for advanced gas therapies.
• Further research into biosafety, challenges, and rational construction is needed for clinical translation.
• GGNs hold significant potential for future patient benefit in clinical settings.