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Mechanically-driven expandable patch promotes tracheal defect reconstruction via synergistic microcurrent and
Zhenyu Zhao1,2, Jing Liao3, Long Wang1,2
1Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Nature Communications
|May 4, 2026
Summary
This study introduces a 3D-printed piezoelectric patch that uses ultrasound to promote tracheal repair. The patch delivers controlled regenerative signals, improving tissue regeneration and vascular reconstruction for severe respiratory disorders.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Medical Devices
Background:
- Tracheal defects cause severe respiratory issues, often leading to complications like graft rejection and poor vascularization.
- Current treatments for tracheal defects face limitations in delivering controlled regenerative signals, hindering tissue repair and vascular reconstruction.
Purpose of the Study:
- To design a novel 3D-printed piezoelectric system for enhanced tracheal defect repair.
- To investigate the synergistic effects of mechanical energy transduction and ultrasound activation for promoting tissue regeneration and vascularization.
Main Methods:
- Development of a mechanically driven, 3D-printed piezoelectric patch (PFT).
- Utilizing exogenous ultrasound to activate the patch, converting mechanical energy into therapeutic cues.
- Evaluating the patch's ability to achieve defect occlusion and stimulate vascular reconstruction.
Main Results:
- The PFT system effectively transduces mechanical energy into regenerative signals upon ultrasound activation.
- Ultrasound-induced patch expansion facilitated defect occlusion and enhanced vascular reconstruction.
- The system demonstrated coordinated improvement in structural sealing and tissue regeneration for tracheal defects.
Conclusions:
- The developed piezoelectric patch offers a promising strategy for integrated tracheal defect repair.
- This mechanically driven system provides a sustainable method for enhancing regenerative therapies in vascularized organs.
- The technology has broad applicability for improving regenerative outcomes in various organ systems.
