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Synthesis of Indoxyl-glycosides for Detection of Glycosidase Activities
Published on: May 27, 2015
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Two New Phenolic Glycosides from Sorbus commixta
Chung Sub Kim1, Joonseok Oh2,3, Lalita Subedi4,5
1Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University.
Chemical & Pharmaceutical Bulletin
|August 3, 2018
Summary
Two novel phenolic glycosides, sorcomisides A and B, were identified from Sorbus commixta bark. These compounds, along with 10 known ones, were evaluated for neuroprotective, anti-inflammatory, and cytotoxic effects.
Area of Science:
- Phytochemistry and Natural Products Chemistry
- Medicinal Chemistry
Background:
- The stem bark of Sorbus commixta is a potential source of bioactive natural products.
- Phenolic glycosides are a class of compounds known for diverse biological activities.
Purpose of the Study:
- To isolate and characterize new compounds from Sorbus commixta stem bark.
- To evaluate the neuroprotective, anti-inflammatory, and cytotoxic potential of isolated compounds.
Main Methods:
- Isolation of compounds using chromatographic techniques.
- Structure elucidation using spectroscopic methods (1D- and 2D-NMR) and high-resolution mass spectrometry (HR-MS).
- Chemical reactions and computational methods for structural confirmation.
Main Results:
- Two new phenolic glycosides, sorcomisides A and B, were identified.
- Ten known compounds were also isolated and characterized.
- All 12 isolated compounds were screened for biological activities.
Conclusions:
- Sorbus commixta stem bark yields novel phenolic glycosides with potential bioactivity.
- Further investigation is warranted to explore the therapeutic applications of sorcomisides A and B.
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